| Pair Name | Aloe emodin, Doxorubicin | ||
| Phytochemical Name | Aloe emodin (PubChem CID: 10207 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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MOL
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| Structure of Anticancer Drug |
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| Pair Name | Aloe emodin, Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Down-regulation | Activity | ABCB1 | hsa5243 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| Result | Our study indicated that AE could be a potential reversal agent to resensitize ADR resistant in tumor chemotherapy and inhibiting autophagy might be an effective strategy to further enhance the reversal activity of AE. | |||
| No. | Title | Href |
|---|---|---|
| 1 | The effects and mechanisms of aloe-emodin on reversing adriamycin-induced resistance of MCF-7/ADR cells. Phytother Res. 2021 Jul;35(7):3886-3897. doi: 10.1002/ptr.7096. | Click |
